Differences in drug transporter genes may affect diabetes drug response

In type 2 diabetes, blood sugar levels are too high. Over time, high blood sugar can damage the kidneys, heart, eyes, nerves and other organs. Many people with diabetes take the drug metformin to help control blood sugar. But the drug works better for some people than others. Drug transporters move drugs back and forth between your blood and cells. Scientists think that slight inherited differences in drug transporter genes may affect how well metformin works. In this project, researchers are using BioVU samples to look for these gene differences in patients with type 2 diabetes. They want to see if these gene differences explain how well metformin helps control patients’ blood sugar.