Genetics of circulating hormone levels

Genetics of Circulating Hormone Levels

Circulating hormone levels can be abnormal during certain heart conditions, which include Torsades-de-Pointes, and Atrial Fibrillation.

What is Torsades-de-Pointes?

Torsades-de-Pointes is a type of abnormal heart rhythm. Your heart beats in a steady, regular rhythm. But when someone has Torsades-de-Pointes, their heart starts to beat in a chaotic, irregular way. This can cause a person to feel dizzy, have a rapid heartbeat, or even faint. It’s important to treat this condition quickly because it can sometimes lead to more serious heart problems.

What is Atrial Fibrillation? 

Atrial fibrillation, or AFib, is when your heart beats in an uneven and often very fast way. AFib can cause blood clots in your heart, which increases your chances of having a stroke, heart failure, and other heart problems. In AFib, the top parts of your heart, called the atria, beat in a disorganized and uneven way compared with the bottom parts of your heart, known as the ventricles. Some people with AFib might not feel any different, but others might feel like their heart is racing or pounding, feel short of breath, or feel dizzy. While AFib itself isn’t usually life-threatening, it’s a serious health issue that needs to be treated correctly to prevent other concerns.

How was the research done?

Researchers use data from BioVU to look at the levels of hormones in the body and their genetic links. Using this data, they aim to create genetic indicators of hormone levels. Researchers use these indicators to predict hormone levels in people. They aim to see if there is any link between these predicted hormone levels and Torsades-de-Pointes or Atrial Fibrillation. 

What is the significance of this study?

Certain hormones in our body can influence the health of our heart and blood vessels, and lead to diseases. Female hormones can increase the chances of Torsades-de-Pointes in women. While male hormones can make men more prone to Atrial Fibrillation. This study could help researchers understand more about how hormones affect heart health. Which can potentially lead to new ways of treating or preventing these conditions.