Genetics of Juvenile Arthritis (JIA)

Published by Alicia Ferguson on

Genetics of Juvenile Idiopathic Arthritis 
What is Juvenile Idiopathic Arthritis? 

Juvenile Idiopathic Arthritis (JIA) is a type of arthritis caused by the body’s immune system mistakenly attacking joint cells. This autoimmune disorder is found in children under the age of 16. It can affect any joint, and in severe cases, it can affect a child’s growth. JIA is believed to develop as a result of genetic and environmental factors.


Symptoms of this condition include: 

  • Swelling and pain around joints
  • Stiffness around joints
  • Fever or rash 

Treatment usually involves medications and physical therapy to reduce symptoms and prevent damage to the joints. 

How is the research done? 

Scientists want to know if certain genes might make a person more likely to get Juvenile Idiopathic Arthritis (JIA). They also want to see if there’s a gene that could make someone with JIA have a stronger immune response and more inflammation than others. To do this, they’re going to study people with and without JIA to see if there are any differences in the way their genes work. They’ll also check if there’s a connection between how these genes work and certain things about people with JIA, like how old they were when they got sick, the specific type of JIA they have, or the kind of medicine they need. This could help them understand if certain genes are connected to these factors.

What is the importance of this study? 

More research is needed to learn about what causes Juvenile Idiopathic Arthritis (JIA). This study is really important because it could help us understand if genes play a part in kids developing  this disease. It might also help us see how genes relate to when the disease is found, how well medicines work, and what happens to the patient.