Genetics of postpartum hemorrhage

Genetics of Postpartum Hemorrhage

What is Postpartum Hemorrhage?

Postpartum hemorrhage (PPH) is severe bleeding after giving birth. It’s a serious and dangerous condition. PPH usually occurs within 24 hours of childbirth, but it can happen up to 12 weeks postpartum. When the bleeding is caught early and treated, it leads to more successful outcomes.

PPH is when the total amount of blood loss after delivery is much more than the expected amount. With both a vaginal or a Cesarean section delivery, bleeding can be severe enough to cause symptoms, such as a significant change in heart rate or blood pressure.

How was the study done?

This study plans to use de-identified information from BioVU. Researchers want to compare women with PPH following vaginal or cesarean delivery with a control group of women who do not experience PPH. Researchers plan to identify possible genetic differences between these two groups.

What is the importance of this study?

PPH is a serious problem that affects a small percentage of pregnancies worldwide. It is the leading cause of pregnancy issues and death, causing 140,000 deaths globally every year. While doctors know some factors that increase the risk of PPH, they don’t understand the underlying causes very well. Current treatments are not always successful, so more research is needed. This study aims to improve the ability to predict PPH after vaginal and cesarean deliveries by looking at how a person’s genes may contribute to the risk.