Probing a genetic cause of Cushing’s syndrome

Cushing’s syndrome happens when the body has too much of the hormone cortisol. The most obvious sign of Cushing’s syndrome is rapid weight gain around the belly. The condition can lead to diabetes and high blood pressure. If not treated, Cushing’s syndrome can be deadly. There are some medicines to treat the condition. But these do not work very well. They also may cause serious side effects. Better treatments are needed for this condition. In this project, researchers are looking for changes in a gene called MC3R in people with Cushing’s. This study may reveal a new cause of Cushing’s syndrome in humans. This may also help us find better ways to treat it.