Genetics of maternal obesity and the trophoblast transcriptome

Genetics of Maternal Obesity and the Trophoblast Transcriptome

What is the Trophoblast Transcriptome (TT)?

The TT is the collection of all genes that are active in the placenta. The trophoblast is a layer of cells in the placenta that helps to nourish the developing baby. The study is looking at these genes in people of all ages because those genes are part of the developmental origins of health and disease (DOHAD). 

How was the research done?

Researchers are using genetic results from blood samples to predict gene expression that would have occurred in an individual while they were in the womb. Those predicted placental genes can be linked to disease risks that were observed later in life. The placenta is the connection between the mother and child during development. The placenta can sometimes pass along certain disease risk factors that the child could eventually develop during life. 

What is the significance of this study?

The purpose of this study is to better understand the connection between gene expression and adult diseases. Furthering the research and being able to understand the significance of genes and how they are linked to certain diseases will allow researchers to better predict and detect later life diseases. Early detection would allow people to be prepared and receive improved treatments.